Patents: US9029315B2/CN103261217B/EP2910572B1
Introduction
The PD-1 isoform is a unique isoform of the immune checkpoint PD-1 molecule. As opposed to the immunoregulatory function of the wildtype PD-1 molecule, the PD-1 isoform promotes pro-inflammatory reactions.
Key characteristics of PD-1-based DNA vaccine
PD-1-based DNA vaccine platform can be efficiently applied to generate highly efficacious DNA vaccines for various infectious diseases and cancers which have clear advantages over traditional vaccine in terms of development time, stability, safety, cost, and more importantly, effectiveness.
PD-1-based DNA vaccine platform explained
A PD‑1-based DNA vaccine is generated by cloning an optimised DNA sequence encoding PD‑1‑linked antigen to our DNA plasmid backbone. The vaccine is then administered intramuscularly with electroporation. Electroporation enhances the delivery of the DNA vaccine into muscle cells. The muscle cells will act as mini-factories to produce PD-1-linked antigens. The PD‑1 domain of the antigen will allow effective antigen targeting to dendritic cells, an essential cell type for inducing potent T cell and B cell responses. This process builds up protective memory immunity in the body to fight off virus infections and cancers.
References:
Zhou J, Cheung AK, Liu H, Tan Z, Tang X, Kang Y, et al. Potentiating functional antigen-specific CD8+ T cell immunity by a novel PD1 isoform-based fusion DNA vaccine. Molecular Therapy. 2013 Apr 16;21(7):1445–55. Available from: https://doi.org/10.1038/mt.2013.63
Zhou J, Cheung AKL, Tan Z, Wang H, Yu W, Du Y, et al. PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice. Journal of Clinical Investigation. 2013 Apr 30;123(6):2629–42. Available from: https://doi.org/10.1172/jci64704
Immuno Cure is Rebranded!
醫克生物已重塑品牌!
www.immunocure.hk >>>>>> www.yicura.hk
